Tumor-Induced Immune Suppression: Mechanisms and Therapeutic Reversal

Tumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal focuses on the critical question of tumor biology: "Why can tumors escape immune system control?" It also addresses one of the most important problems within the field of clinical oncology: the lack of efficient cancer vaccines. Edited by Dmitry Gabrilovich and Andy Hurwitz, the book is the first attempt at a systematic and comprehensive analysis of the various immunosuppressive mechanisms in cancer. This analysis includes information on:

• Different surface molecules that mediate T-cell suppression in cancer;
• The specific roles of dendritic cells, macrophages, and myeloid-derived suppressor cells in tumor non-responsiveness;
• The contribution of regulatory T cells in the inability of immune systems to mount antitumor response;
• The role of T-cell signaling and different metabolic pathways in tumor-associated immune suppression.

This volume connects a multitude of different immunosuppressive mechanisms into one cohesive picture. Most of the chapters not only describe the biological phenomena, but also suggest specific approaches to their correction.

This book should be of high interest for researchers in the fields of tumor immunology and general immunology, as well as for those who are involved in clinical oncology and cancer immunotherapy.